ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Weiwei Yang, Yanhua Zheng, Yan Xia, +6

Nature Cell Biology

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseMolecular Biology +8

Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity

Dexing Fang, David H. Hawke, Yanhua Zheng, +7

Journal of Biological Chemistry

Molecular RegulationCellular PhysiologyTumor BiologyTumor InvasionTranscriptional Regulation +17

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Weiwei Yang, Yan Xia, David H. Hawke, +7

Cell

Histone ModificationsChromatinTranscriptional RegulationCell RegulationChromatin Remodeling +13

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

Zhimin Lu, Sourav Ghosh, Zhiyong Wang, +1

Cancer Cell

Tumor BiologyDevelopmental BiologySignaling PathwayMedicineCancer Cell Biology +7

Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

Bing‐Hua Jiang, Guanmin Jiang, Juan Zheng, +3

PubMed

Phosphatidylinositol 3-KinaseRedox BiologyCellular PhysiologyTumor BiologyOxidative Stress +15

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

Yugang Wang, Yusong R. Guo, Ke Liu, +15

Nature

ChromatinSignal TransductionHistone H3 SuccinyltransferaseBiochemistryα-Kgdh Complex Acts +9

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

Xinjian Li, Yuhui Jiang, Jill Meisenhelder, +9

Molecular Cell

Signal TransductionTca CycleReceptor Tyrosine KinaseProtein KinaseCell Cycle +7

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα

Dong Guo, Yingying Tong, Xiaoming Jiang, +13

Cell Metabolism

Tumor BiologyImmune EvasionAerobic Glycolysis PromotesCancer ImmunosurveillanceCell Regulation +11

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

Daqian Xu, Zheng Wang, Yan Xia, +15

Nature

Gluconeogenic Enzyme Pck1Signal TransductionBiochemistryMedicineCell Biology +3

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

Xinjian Li, Willie Yu, Xu Qian, +11

Molecular Cell

ChromatinTranscriptional RegulationMitophagyDevelopmental BiologyCell Regulation +6