Yuhua Huang

Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Srikanth Venkatraman, Stéphane Bogen, Ashok Arasappan et al. · Journal of Medicinal Chemistry · 2006 · 282 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst

Mingxin Chang, Yuhua Huang, Shaodong Liu et al. · Angewandte Chemie International Edition · 2014 · 101 citations

Natural Sciences, Chemistry, Catalysis +14

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor

Ashok Arasappan, Frank Bennett, Stéphane Bogen et al. · ACS Medicinal Chemistry Letters · 2010 · 98 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Cyclic Sulfones as Novel P3-Caps for Hepatitis C Virus NS3/4A (HCV NS3/4A) Protease Inhibitors: Synthesis and Evaluation of Inhibitors with Improved Potency and Pharmacokinetic Profiles

Francisco Velázquez, Mousumi Sannigrahi, Frank Bennett et al. · Journal of Medicinal Chemistry · 2010 · 70 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles

G. Anilkumar, Charles A. Lesburg, Oleg Selyutin et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 49 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14