The Mechanism of Excessive Intestinal Inflammation in Necrotizing Enterocolitis: An Immature Innate Immune Response

N. Nanda Nanthakumar, Di Meng, Allan M. Goldstein, +6

PLoS ONE

Innate Immune SystemImmunologyPathologyInnate ImmunityExcessive Inflammatory Response +17

Developmentally regulated IκB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation

Erika C. Claud, Lei Lu, Pauline M. Anton, +3

Proceedings of the National Academy of Sciences

Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants

Erika C. Claud, Kevin Keegan, Jennifer M. Brulc, +6

Microbiome

Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation

Kriston Ganguli, Di Meng, Samuli Rautava, +3

American Journal of Physiology-Gastrointestinal and Liver Physiology

Innate Immune-mediated InflammationTlr4 MrnaDysbiosisMicrobial PathogensInnate Immune System +22

Microbiota influence the development of the brain and behaviors in C57BL/6J mice

Jing Lü, Sylvia Synowiec, Lei Lu, +8

PLoS ONE

NeuropsychologyDysbiosisBrain FunctionHost-microbe InteractionsBrain Development +25

Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice

Jing Lü, Lei Lu, Yueyue Yu, +3

Scientific Reports

DysbiosisBrain DevelopmentProbioticGut MicrobiologyGut-organ Axis +18

Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease

Rene Cortese, Lei Lu, Yueyue Yu, +2

Epigenetics

DysbiosisMicrobial PathogensHost-microbe InteractionsImmunologyEpigenome-microbiome Crosstalk +19

Erythropoietin Protects Epithelial Cells from Excessive Autophagy and Apoptosis in Experimental Neonatal Necrotizing Enterocolitis

Yueyue Yu, Sheng-Ru Shiou, Yuee Guo, +5

PLoS ONE

ApoptosisImmunologyGastroenterologyPathologyCell Death +15

Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model

Yueyue Yu, Lei Lu, Jun Sun, +2

American Journal of Physiology-Gastrointestinal and Liver Physiology

ProbioticDysbiosisHost-microbe InteractionsMpi-l MicrobiotaMicrobiota +12

Lactobacillus rhamnosus GG and its SpaC pilus adhesin modulate inflammatory responsiveness and TLR-related gene expression in the fetal human gut

Kriston Ganguli, María Carmen Collado, Jaana Rautava, +10

Pediatric Research

InflammationProbioticDysbiosisTlr-related Gene ExpressionGut Microbiology +6