Ming Guo

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern et al. · Proceedings of the National Academy of Sciences · 2008 · 650 citations · Full text

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

Qian Cai, Haiying Sun, Yuefeng Peng et al. · Journal of Medicinal Chemistry · 2011 · 265 citations · Full text

Discovery of 4-((3′<i>R</i>,4′<i>S</i>,5′<i>R</i>)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

Angelo Aguilar, Jianfeng Lü, Liu Liu et al. · Journal of Medicinal Chemistry · 2017 · 193 citations · Full text

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Hudie Wei, Haolan Wang, Genxin Wang et al. · Nature Communications · 2023 · 84 citations · Full text

Catecholamine-induced mechanical sensitization of cutaneous nociceptors in the rat

Michael S. Gold, D. M. White, Sara Ahlgren et al. · Neuroscience Letters · 1994 · 34 citations

Health Sciences, Pain Medicine, Medicine +8