Carlotta Granchi

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Maria Apicella, Elisa Giannoni, Stephany Fiore et al. · Cell Metabolism · 2018 · 290 citations · Full text

Medicine, Cancer Biology, Oncology +14

Discovery of <i>N</i>-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

Carlotta Granchi, Sarabindu Roy, Chiara Giacomelli et al. · Journal of Medicinal Chemistry · 2011 · 221 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

Mina Maftouh, Abolfazl Avan, Rocco Sciarrillo et al. · British Journal of Cancer · 2013 · 178 citations · Full text

Medicine, Oncology, Pharmacology +17

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Simon J. Allison, John R. P. Knight, Carlotta Granchi et al. · Oncogenesis · 2014 · 142 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +17

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Simona Daniele, Chiara Giacomelli, Elisa Zappelli et al. · Scientific Reports · 2015 · 85 citations · Full text

Medicine, Cancer Biology, Oncology +13