Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Maria Apicella, Elisa Giannoni, Stephany Fiore, +14

Cell Metabolism

MedicineEgfr Targeted TherapiesLactate SecretionBreast CancerCancer Cells +8

Discovery of <i>N</i>-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

Carlotta Granchi, Sarabindu Roy, Chiara Giacomelli, +15

Journal of Medicinal Chemistry

Bioorganic ChemistryAldo-keto ReductaseMetabolic RemodelingRedox BiologyTumor Biology +17

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

Mina Maftouh, Abolfazl Avan, Rocco Sciarrillo, +10

British Journal of Cancer

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Simon J. Allison, John R. P. Knight, Carlotta Granchi, +4

Oncogenesis

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Daniela Massihnia, Amir Avan, Niccola Funel, +11

Journal of Hematology & Oncology

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Simona Daniele, Chiara Giacomelli, Elisa Zappelli, +4

Scientific Reports

Anticancer agents interacting with membrane glucose transporters

Carlotta Granchi, Serena Fortunato, Filippo Minutolo

MedChemComm

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

Carlotta Granchi, Sarabindu Roy, Alessio De Simone, +12

European Journal of Medicinal Chemistry

Medicinal ChemistryMedicineLactate DehydrogenaseAnti-cancer AgentPharmacology +1

Identification and characterization of a new reversible MAGL inhibitor

Tiziano Tuccinardi, Carlotta Granchi, Flavio Rizzolio, +6

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineNatural SciencesMechanism Of ActionPharmacotherapy +4

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

Carlotta Granchi, Emilia Calvaresi, Tiziano Tuccinardi, +5

Organic & Biomolecular Chemistry

Chemoprevention StrategyGlycobiologyTumor BiologyDifferential ActionMedicinal Chemistry +14