Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

Simona Daniele, Barbara Costa, Elisa Zappelli, +8

Scientific Reports

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death

Simona Daniele, Chiara Giacomelli, Elisa Zappelli, +4

Scientific Reports

Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy

Simona Daniele, Elisa Zappelli, Lucia Natali, +2

Cell Death and Disease

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization

Marta Fumagalli, Elisabetta Bonfanti, Simona Daniele, +5

Glia

Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK

Simona Daniele, Eleonora Da Pozzo, Elisa Zappelli, +1

Cellular Signalling

Immune RegulationImmunologyPharmacotherapyNeuroinflammationInflammation +14

Does GRK–β arrestin machinery work as a “switch on” for GPR17-mediated activation of intracellular signaling pathways?

Simona Daniele, Maria Letizia Trincavelli, Marta Fumagalli, +6

Cellular Signalling

Signal TransductionSignaling PathwayCell RegulationG Protein-coupled ReceptorMolecular Regulation +9

Two mixed valence diruthenium(<scp>ii</scp>,<scp>iii</scp>) isomeric complexes show different anticancer properties

Elisabetta Barresi, Iogann Tolbatov, Tiziano Marzo, +8

Dalton Transactions

Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes

Simona Daniele, Elisa Zappelli, Claudia Martini

Journal of Neuroinflammation

Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors

Margarida Espadinha, Elizabeth A. Lopes, Vanda Marques, +9

European Journal of Medicinal Chemistry

Endometrial Dysbiosis Is Related to Inflammatory Factors in Women with Repeated Implantation Failure: A Pilot Study

Vito Cela, Simona Daniele, Maria Elena Rosa Obino, +10

Journal of Clinical Medicine

DysbiosisMicrobial PathogensImmunologyGynecologyMenstrual Cycle +24