Xiadi He

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Zhentao Yang, Yan Wang, Yingying Zhang et al. · Nature Cell Biology · 2018 · 276 citations

Biochemistry, Mitochondrial Function, Physiology +12

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

Li Feng, Xiadi He, Dingwei Ye et al. · Molecular Cell · 2015 · 241 citations · Full text

Reductive Stress, Impairs Mitochondria Respiration, Induces Apoptosis Resistance +8

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

Yun-Zi Mao, Jiaojiao Zhang, Qian Zhou et al. · Cell Research · 2024 · 235 citations · Full text

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

Qiwei Wang, Johann S. Bergholz, Liya Ding et al. · Nature Communications · 2022 · 229 citations · Full text

Lactate regulates cell cycle by remodelling the anaphase promoting complex

Weihai Liu, Yun Wang, Luiz H. M. Bozi et al. · Nature · 2023 · 181 citations · Full text

Anaphase Promoting Complex, Signal Transduction, Developmental Biology +10