Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade

Linpeng Li, Keshi Chen, Tianyu Wang, +20

Nature Metabolism

Epigenome–metabolome–epigenome Signalling CascadeTranscriptional RegulationSignal TransductionDevelopmental BiologySignaling Pathway +8

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Leilei Chen, Carmen Morcelle, Zhou‐Li Cheng, +34

Nature Cell Biology

InflammationInflammatory ResponsesImmunologyReactive Oxygen SpecieGene Expression +3

Jasmonic acid involves in grape fruit ripening and resistant against Botrytis cinerea

Haifeng Jia, Cheng Zhang, Tariq Pervaiz, +7

Functional & Integrative Genomics

Botrytis CinereaJasmonic AcidPlant PathologyMicrobiologyRipening +3

Metabolic remodelling during early mouse embryo development

Jing Zhao, Ke Yao, Hua Yu, +23

Nature Metabolism

Developmental BiologyMorphogenesisMetabolic RegulationEmbryonic DevelopmentMetabolism +2

Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy

Yujia Chen, Guan-Nan Li, Xian-Jing Li, +18

Science Advances

The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response

Yirong Zeng, Junbin Song, Dezheng Wang, +8

Journal of Clinical Investigation

AsthmaInflammatory Lung DiseaseMicrobial PathogensLung InflammationImmunology +17

Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation

Yi Wu, Keshi Chen, Linpeng Li, +17

Cell Death and Differentiation

Molecular PhysiologyMedicineLipid ScienceLipidomic RemodelingPharmacology +4

Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation

Jiaojiao Zhang, Tingting Fan, Yun-Zi Mao, +14

Nature Metabolism

ChromatinBiochemistryCell DivisionNatural SciencesChromatin Remodeling +11

Radiogenomics Map Reveals the Landscape of m6A Methylation Modification Pattern in Bladder Cancer

Fangdie Ye, Yun Hu, Jiahao Gao, +5

Frontiers in Immunology

Epigenetic ChangePathologyRadiomics AlgorithmEpigeneticsTumor Heterogeneity +16

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

Yukun Xia, Yirong Zeng, Mengli Zhang, +16

Protein & Cell