Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes

Jinyi Zhang, Amro Shehabeldin, L.A.G. da Cruz, +9

The Journal of Experimental Medicine

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

Gideon M. Hirschfield, Xiangdong Liu, Younghun Han, +21

Nature Genetics

HepatologyBiliary TractLiver PhysiologyGeneticsImmunology +10

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

Yan Leng, Jinyi Zhang, Karen Badour, +5

Proceedings of the National Academy of Sciences

Molecular RegulationMolecular BiologyCytoskeletonCellular PhysiologySignaling Pathway +17

Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation

Karen Badour, Jinyi Zhang, Fabio Shi, +3

The Journal of Experimental Medicine

The Wiskott-Aldrich Syndrome Protein Acts Downstream of CD2 and the CD2AP and PSTPIP1 Adaptors to Promote Formation of the Immunological Synapse

Karen Badour, Jinyi Zhang, Fabio Shi, +5

Immunity

Signal TransductionAutoimmune DiseaseMedicineImmunologyPromote Formation +8

Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis

Peter A. Merkel, Gang Xie, Paul A. Monach, +40

Arthritis & Rheumatology

Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology

Sonja Majstoravich, Jinyi Zhang, Susan Nicholson-Dykstra, +4

Blood

Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist

Eva W. Iepsen, Jinyi Zhang, Henrik S. Thomsen, +7

Cell Metabolism

ObesityMetabolic SyndromeFunctional SelectivityMedicinePhysiology +8

The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis

Mary K. H. McGavin, Karen Badour, Lynne A Hardy, +3

The Journal of Experimental Medicine

Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3⁺ Treg

Rahul Kushwah, Jing Wu, Jordan Oliver, +4

European Journal of Immunology

Viable DcT-regulatory CellImmunologyImmune RegulationCell Death +16