Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

Siew Pheng Lim, Louis Sebastian Sonntag, Christian G. Noble, +18

Journal of Biological Chemistry

Discovery of Dengue Virus NS4B Inhibitors

Qing-Yin Wang, Hongping Dong, Bin Zou, +19

Journal of Virology

Medicinal ChemistryAntimicrobial Drug DiscoveryDengue VirusMedicineImmunology +12

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

Stephanie Moquin, Oliver Simon, Ratna Karuna, +36

Science Translational Medicine

Pan-serotype InhibitorDengue VirusImmunologyAntiviral DrugNovartis Compound Library +14

Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors

Bin Zou, Wai Ling Chan, Mei Ding, +20

ACS Medicinal Chemistry Letters

Novel Dengue VirusOptimal Compound 14ALead IdentificationAntiviral DrugChemical Biology +17

Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage

Menglan He, Alvin C. Y. Kuk, Mei Ding, +11

Proceedings of the National Academy of Sciences

Proteinlipid InteractionSpns1 DeficiencyMolecular BiologyLipid MovementCellular Physiology +16

Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results

A. Pichota, Jeyaraj Duraiswamy, Zheng Yin, +25

Bioorganic & Medicinal Chemistry Letters

Pulmonary TuberculosisBiochemistryNatural SciencesPeptide LibraryMycobacterium Tuberculosis +6

Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport

Geok Lin Chua, Bryan C. Tan, Randy Y. J. Loke, +9

Proceedings of the National Academy of Sciences

Proteinlipid InteractionSynaptic TransmissionMfsd2a DeficiencyAnalytical UltracentrifugationLipid Movement +21

Pyrroloquinoline Quinine Protects Rat Brain Cortex Against Acute Glutamate-Induced Neurotoxicity

Zhang Qi, Mei Ding, Zheng Cao, +3

Neurochemical Research

NeurophysiologyMedicineNeuropharmacologyNeuroprotectionNeuroscience +7

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, +41

Journal of Medicinal Chemistry

A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′- <i>C</i> -Methylguanosine for the Treatment of Dengue Virus Infection

Ratna Karuna, Fumiaki Yokokawa, Keshi Wang, +21

Antimicrobial Agents and Chemotherapy