John J. Lee

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

John J. Lee, Doris P. von Kessler, Suki Parks et al. · Cell · 1992 · 586 citations

Life Sciences, Genetics, Molecular Biology +11

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

James Kim, Jean Y. Tang, Ruoyu Gong et al. · Cancer Cell · 2010 · 519 citations · Full text

Medicine, Oncology, Pharmacology +14

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

John J. Lee, Rushika M. Perera, Huaijun Wang et al. · Proceedings of the National Academy of Sciences · 2014 · 502 citations · Full text

Medicine, Cancer Biology, Oncology +17

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

Jeffery A. Porter, Doris P. von Kessler, Stephen C. Ekker et al. · Nature · 1995 · 501 citations

Life Sciences, Cell Biology, Molecular Biology +7

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

John J. Lee, James Kim, Dale R. Gardner et al. · Proceedings of the National Academy of Sciences · 2010 · 298 citations · Full text

Medicine, Oncology, Pharmacology +16