Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, +25

Nature Medicine

ProbioticDysbiosisHealth SciencesMedicineMicrobiota +12

Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis

Haiping Hao, Lijuan Cao, Changtao Jiang, +5

Cell Metabolism

InflammationAnti-inflammatoryPathogenesisImmunologyChronic Inflammation +5

HIF1<i>α</i>-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages

Ting Wang, Huiying Liu, Guan Lian, +3

Mediators of Inflammation

Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism

Xingzhong Zhang, Yangming Zhang, Pengcheng Wang, +11

Cell Metabolism

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

Haohao Huang, Song‐Yang Zhang, Yuanyuan Li, +21

Nature Communications

Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation

Yang Zhao, Mingming Zhao, Yan Cai, +7

Kidney International

Mammalian TargetSignal TransductionAngiogenesisSignaling PathwayMedicine +8

Metabolomics analysis reveals that benzo[a]pyrene, a component of PM2.5, promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitro

Song‐Yang Zhang, Danqing Shao, Huiying Liu, +8

Redox Biology

Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight

Song‐Yang Zhang, Kyla Bruce, Zahra Danaei, +9

Cell Metabolism

ObesityMetabolic SyndromeNutritionEnergy HomeostasisBody Composition +10

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

Song‐Yang Zhang, Yongqiang Dong, Pengcheng Wang, +13

EBioMedicine

Adipose Tissue MacrophagesInsulin SignalingAdipose Inflammasome ActivationOxidative StressInflammation +16

Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2

Yingbao Wang, Dixin Chen, Yan Zhang, +18

Circulation