Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates

Meenakshi Balganesh, Neela Dinesh, Sreevalli Sharma, +3

Antimicrobial Agents and Chemotherapy

Tuberculosis PreventionMolecular BiologyAntimicrobial ChemotherapyAntibiotic ResistanceDrug Resistance +19

Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious <i>in Vivo</i>

Pravin S. Shirude, Radha Krishan Shandil, C Sadler, +36

Journal of Medicinal Chemistry

PharmacotherapyAntimicrobial ChemotherapyPharmaceutical ChemistryScaffold Morphing EffortsDrug Resistance +20

Discovery of Imidazo[1,2-<i>a</i>]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

Subramanyam J. Tantry, Shankar D. Markad, Vikas Shinde, +51

Journal of Medicinal Chemistry

Bioorganic ChemistryAntimicrobial ChemotherapyChemical BiologyPharmaceutical ChemistryDrug Resistance +16

1,4-Azaindole, a Potential Drug Candidate for Treatment of Tuberculosis

Monalisa Chatterji, Radha Krishan Shandil, M. R. Manjunatha, +14

Antimicrobial Agents and Chemotherapy

Tuberculosis PreventionPharmacotherapyAntimicrobial ChemotherapyPharmaceutical ChemistryCompound 2 +16

4-Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

Maruti Naik, Vaishali Humnabadkar, Subramanyam J. Tantry, +47

Journal of Medicinal Chemistry

Discovery of Pyrazolopyridones as a Novel Class of Noncovalent DprE1 Inhibitor with Potent Anti-Mycobacterial Activity

Manoranjan Panda, Sreekanth A. Ramachandran, Vasanthi Ramachandran, +14

Journal of Medicinal Chemistry

Antimicrobial ChemotherapyPharmaceutical ChemistryPotent Anti-mycobacterial ActivityMtb StrainDrug Resistance +18

Lead Optimization of 1,4-Azaindoles as Antimycobacterial Agents

Pravin S. Shirude, Radha Krishan Shandil, M. R. Manjunatha, +23

Journal of Medicinal Chemistry

Aminopyrazinamides: Novel and Specific GyrB Inhibitors that Kill Replicating and Nonreplicating <i>Mycobacterium tuberculosis</i>

Pravin S. Shirude, Prashanti Madhavapeddi, Julie A. Tucker, +11

ACS Chemical Biology

Crystal StructureTuberculosis PreventionPharmacotherapyAntimicrobial ChemotherapyPharmaceutical Chemistry +19

<i>In Vitro</i> and <i>In Vivo</i> Efficacy of β-Lactams against Replicating and Slowly Growing/Nonreplicating Mycobacterium tuberculosis

Suresh Solapure, Neela Dinesh, Radha Krishan Shandil, +12

Antimicrobial Agents and Chemotherapy

Microbial PathogensTuberculosis PreventionStrain Ss18bMycobacterium Tuberculosis BacteriaAntimicrobial Chemotherapy +16

Rv1218c, an ABC Transporter of <i>Mycobacterium tuberculosis</i> with Implications in Drug Discovery

Meenakshi Balganesh, Sanjana Kuruppath, Nimi Marcel, +3

Antimicrobial Agents and Chemotherapy

Tuberculosis PreventionBacteriologyMolecular BiologyAntimicrobial ChemotherapyDrug Resistance +21