Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

Qiming Liang, Zhifei Luo, Jianxiong Zeng, +9

Cell stem cell

Cell AutophagyMolecular NeuroscienceDevelopmental BiologyMedicineAutophagy +10

Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets

Su-Jin Park, Kwang-Min Yu, Young‐Il Kim, +16

mBio

Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy

Suan‐Sin Foo, Weiqiang Chen, Yen Chan, +10

Nature Microbiology

Maternal ImmunizationM2-skewed ImmunosuppressionPathogenesisViral PathogenesisImmunology +5

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

Weiqiang Chen, Suan‐Sin Foo, Adam Taylor, +8

Journal of Virology

Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss

Weiqiang Chen, Suan‐Sin Foo, Nestor E. Rulli, +10

Proceedings of the National Academy of Sciences

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

Weiqiang Chen, Suan‐Sin Foo, Ali Zaid, +21

Nature Microbiology

InflammationSpecific InhibitionAlphavirus-induced InflammationAutoimmune DiseaseDisease Mechanism +8

<p>4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation</p>

Yang Li, Xing Chen, Hua Zhang, +6

Drug Design Development and Therapy

Susceptibility and Response of Human Blood Monocyte Subsets to Primary Dengue Virus Infection

Kok Loon Wong, Weiqiang Chen, Thavamalar Balakrishnan, +3

PLoS ONE

Adaptive Immune SystemInnate Immune SystemImmunologyViral PathogenesisImmune Regulation +21

Association Between Neonatal Neuroimaging and Clinical Outcomes in Zika-Exposed Infants From Rio de Janeiro, Brazil

Kara‐Lee Pool, Kristina Adachi, Stellios Karnezis, +27

JAMA Network Open

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8

Xin Wu, Tian Xia, Woo-Jin Shin, +13

mBio