Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

Xiuxing Wang, Briana C. Prager, Qiulian Wu, +26

Cell stem cell

Neuro-oncologyLineage PlasticityGlioblastoma Stem CellsGliomaMedicine +7

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Zhen Dong, Guoxin Zhang, Meng Qu, +17

Cancer Discovery

Glioma Stem Cell–Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling

Ryan C. Gimple, Reilly L. Kidwell, Leo J.Y. Kim, +23

Cancer Discovery

Cellular origin of glioblastoma and its implication in precision therapy

Maojin Yao, Shu Li, Xiaojun Wu, +5

Cellular and Molecular Immunology

Neuro-oncologyCellular OriginBrain Tumor BiologyPathologyHigh-grade Gliomas +8

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N-methyladenosine

Deguan Lv, Ryan C. Gimple, Cuiqing Zhong, +15

Developmental Cell

Neuro-oncologyMitophagyGlioblastoma Stem CellsGliomaAutophagy +7

Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC

Guoxin Zhang, Zhen Dong, Briana C. Prager, +7

JCI Insight

Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases

Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, +14

Science Translational Medicine

Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe

Guoxin Zhang, Zhen Dong, Ryan C. Gimple, +22

The Journal of Experimental Medicine

Cell DeathCancer BiologyGliomaMitotic CatastropheTumor Biology +16

RETRACTED: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells

Jia Shen, Zhixin Qiu, Qiulian Wu, +13

Molecular Cell

Cancer ResearchMedicineFbxo7/eya2-scffbxw7 AxisImmunologyTumor Immunity +8

Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting

Ryan C. Gimple, Guoxin Zhang, Shuai Wang, +17

JCI Insight

Pdgfr Tyrosine KinaseStem Cell BiologyCancer BiologyGliomaTumor Biology +17