Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Chun Chen, Jianming Liao, Yiyuan Xia, +7

Gut

Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

Chun Chen, Eun Hee Ahn, Seong Su Kang, +3

Science Advances

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

Chun Chen, Zhihao Wang, Zhentao Zhang, +4

Proceedings of the National Academy of Sciences

Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease

Chun Chen, Yunzhe Zhou, Hualong Wang, +6

The EMBO Journal

InflammationNeurodegenerative DiseasesAlzheimer's DiseaseMedicineImmunology +11

Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology

Kaj Blennow, Chun Chen, Claudia Cicognola, +16

Brain

Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease

Jianming Liao, Chun Chen, Eun Hee Ahn, +6

Neuropharmacology

Alzheimer's DiseaseDementiaBdnf/trkb PathwayNeurochemical BiomarkersProtein Misfolding +7

Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

Chun Chen, Eun Hee Ahn, Xia Liu, +4

ACS Chemical Neuroscience

Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes

Fengxiang Zhang, Minglong Chen, Qijun Shan, +6

Acta Pharmacologica Sinica

CardiomyopathyAgingPhysiologyHypoxia (Medicine)Hypoxia Reoxygenation Induces +6

C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis

Kecheng Lei, Seong Su Kang, Eun Hee Ahn, +7

Molecular Cancer Therapeutics

Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer’s disease pathogenesis

Zhourui Wu, Chun Chen, Seong Su Kang, +6

Proceedings of the National Academy of Sciences