Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Chun Chen, Jianming Liao, Yiyuan Xia, +7

Gut

In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells

Yun Wang, Zhenpeng Qiu, Benhong Zhou, +5

Toxicology in Vitro

MedicineLipid PeroxidationPathologyEllagic AcidHepatotoxicity +6

Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia/reperfusion injury through the JAK/STAT signaling pathway

Pian Gong, Zhan Zhang, Yichun Zou, +7

European Journal of Pharmacology

Cerebral Vascular RegulationIschemia/reperfusion InjuryMedicineCell DeathBlood-brain Barrier Disruption +11

SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway

Jianming Liao, Xiang Tao, Qianshan Ding, +7

Oncology Reports

Ssrp1 DepletionSsrp1 OverexpressionWorld Health OrganizationHigh-grade GliomasCancer Biology +17

Identification of glioblastoma gene prognosis modules based on weighted gene co-expression network analysis

Pengfei Xu, Jian Yang, Junhui Liu, +6

BMC Medical Genomics

TIPE3 is a regulator of cell apoptosis in glioblastoma

Fanen Yuan, Baohui Liu, Yang Xu, +13

Cancer Letters

Neuro-oncologyGliomaCell ApoptosisMedicineApoptosis +5

Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease

Jianming Liao, Chun Chen, Eun Hee Ahn, +6

Neuropharmacology

Alzheimer's DiseaseDementiaBdnf/trkb PathwayNeurochemical BiomarkersProtein Misfolding +7

FSH and ApoE4 contribute to Alzheimer’s disease-like pathogenesis via C/EBPβ/δ-secretase in female mice

Jing Xiong, Seong Su Kang, Mengmeng Wang, +10

Nature Communications

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

Jing Xiong, Jianming Liao, Xia Liu, +4

Nature Communications

PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells

Pengfei Xu, Jian Yang, Junhui Liu, +5

Oncology Reports

ApoptosisHuman Glioblastoma CellsCell DeathHigh-grade GliomasPi3kβ Inhibitor Azd6482 +15