β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

Bernhard W. Renz, Ryota Takahashi, Takayuki Tanaka, +27

Cancer Cell

Tumor BiologyPancreatic CancerMedicinePathologyPharmacology +1

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

Bernhard W. Renz, Takayuki Tanaka, Masaki Sunagawa, +22

Cancer Discovery

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

Yoku Hayakawa, Yoshihiro Hirata, Hayato Nakagawa, +14

Proceedings of the National Academy of Sciences

Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop

Xiaowei Chen, Huan Deng, Michael Churchill, +32

Cell stem cell

Hematological MalignancyHistamine-dependent Feedback LoopBone Marrow FailureMedicineStem Cell Mobilization +9

Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

Makoto Sano, Hideaki Ijichi, Ryota Takahashi, +11

Oncogenesis

Interleukin-6 Mediates Epithelial–Stromal Interactions and Promotes Gastric Tumorigenesis

Hiroto Kinoshita, Yoshihiro Hirata, Hayato Nakagawa, +11

PLoS ONE

Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer

Keisuke Yamamoto, Keisuke Tateishi, Yotaro Kudo, +17

Oncotarget

ImmunologyImmunotherapeuticsCancer BiologyTumor BiologyPdac Cells +17

Interleukin-1β-induced pancreatitis promotes pancreatic ductal adenocarcinoma via B lymphocyte–mediated immune suppression

Ryota Takahashi, Marina Macchini, Masaki Sunagawa, +13

Gut

Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

Moritz Middelhoff, Henrik Nienhüser, Giovanni Valenti, +13

Nature Communications

Role of Interleukin-32 in Helicobacter pylori-Induced Gastric Inflammation

Kosuke Sakitani, Yoshihiro Hirata, Yoku Hayakawa, +10

Infection and Immunity

InflammationCytokineMucosal ImmunologyMicrobial PathogensImmunology +12