Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

Yi Wang, Yuanyuan Qian, Qilu Fang, +8

Nature Communications

Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice

Chao Zheng, Lan Huang, Wu Luo, +9

Cell Death and Disease

Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents

Zhiguo Liu, Longguang Tang, Peng Zou, +8

European Journal of Medicinal Chemistry

InflammationMedicinal ChemistryPharmaceutical ChemistryAnti-inflammatory AgentsAnti-inflammatory +6

MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

Jibo Han, Chunpeng Zou, Liqin Mei, +8

Basic Research in Cardiology

InflammationMolecular PhysiologyMedicineImmunologyChronic Inflammation +6

Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2)

Zheng Xu, Weixin Li, Jibo Han, +7

Scientific Reports

Novel <scp>EGFR</scp> inhibitors attenuate cardiac hypertrophy induced by angiotensin II

Kesong Peng, Xinqiao Tian, Yuanyuan Qian, +7

Journal of Cellular and Molecular Medicine

HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection

Jian Zhang, Zheng Xu, Junlian Gu, +6

American Journal of Physiology-Endocrinology and Metabolism

Lipid PeroxidationDiabetic MiceHdac3 InhibitionFgf21 SynthesisOxidative Stress +16

EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress

Zheng Xu, Yunjie Zhao, Peng Zhong, +6

Oncotarget

Renal FunctionEgfr InhibitionMedicinePhysiologyDiabetes +13

A Newly Designed Curcumin Analog Y20 Mitigates Cardiac Injury via Anti-Inflammatory and Anti-Oxidant Actions in Obese Rats

Yuanyuan Qian, Peng Zhong, Dandan Liang, +7

PLoS ONE

InflammationMetabolic SyndromeCardiac InflammationAnti-inflammatoryCardiovascular Disease +12

Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress

Zhenxin Mou, Zhiguo Feng, Zheng Xu, +5

Biochemical and Biophysical Research Communications

InflammationExcessive InflammationMedicineDiabetesImmunology +8