Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

Hao Huang, Jianyang Hu, Alishba Maryam, +14

Nature Communications

Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway

Junshan Liu, Chuying Huo, Huihui Cao, +8

Phytomedicine

MedicineLiver PhysiologyApoptosisPharmacologyHepatocellular Carcinoma Cells +8

Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo

Zhenjian Zhuo, Jianyang Hu, Xiaolin Yang, +8

Scientific Reports

Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents

Minfeng Chen, Xueping Lei, Changzheng Shi, +22

Journal of Clinical Investigation

Viable RimNanotherapeuticsCancer BiologyTumor BiologyBlood Vessels +14

Novel cycloartane triterpenoid from Cimicifuga foetida (Sheng ma) induces mitochondrial apoptosis via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation in human breast carcinoma MCF-7 cells

Haiyan Sun, Beibei Liu, Jianyang Hu, +7

Chinese Medicine

Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-catenin

Liping Chen, Weiqian Mai, Minfeng Chen, +10

Pharmacological Research

Chemoprevention StrategyImmunotherapeuticsEmt Marker ExpressionCancer Epithelial-mesenchymal TransitionCancer Biology +16

Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes

Min Zhou, Weiping Li, Jian Li, +8

Journal of Biological Chemistry

The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells

Haiyan Sun, Maohua Huang, Nan Yao, +8

Biochemical Pharmacology

InflammationCytokineAkt OveractivationCell AutophagyMedicine +9

TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis

Jianyang Hu, Yuni Lai, Hao Huang, +12

British Journal of Cancer

Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer

Haiyan Sun, Tong Ou, Jianyang Hu, +8

Biochemical Pharmacology

MitophagyChemoprevention StrategyCell DeathCancer BiologyOxidative Stress +15