Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

Marco Tigano, Danielle Vargas, Samuel Tremblay‐Belzile, +2

Nature

Genome InstabilityDna DamageMitochondrial FunctionNatural SciencesImmunology +7

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Andreas Kloetgen, Palaniraja Thandapani, Panagiotis Ntziachristos, +17

Nature Genetics

ChromatinMixed-phenotype Acute LeukemiaNuclear OrganizationAdult T-cell Leukemia-lymphomaMedicine +3

CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci

Yi Fu, Pedro P. Rocha, Vincent Luo, +4

Nature Communications

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

Jiahuan Chen, Yi Fu, Daniel S. Day, +18

Nature Communications

4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments

Ramya Raviram, Pedro P. Rocha, Christian L. Müller, +8

PLoS Computational Biology

Bait LocusGenetics4C-seq PipelinesMolecular BiologyTranscriptomics Technology +17

Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis

Yi Fu, Olivia Sacco, Emily DeBitetto, +3

Molecular Cell

Reductive StressGenome InstabilityIntegrated Stress ResponseMitochondrial FunctionMitochondrial Dynamic +7

Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile

Huaishan Wang, Kangle Zhai, Yingchao Xue, +10

PLoS ONE

Acute Lung InjuryInflammatory Lung DiseaseTranslocator ProteinLung InflammationGenetics +24

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

Pedro P. Rocha, Ramya Raviram, Yi Fu, +11

Cell Reports

Kindlin-2 deficiency induces fatal intestinal obstruction in mice

Xiaokun He, Jiagui Song, Zeyu Cai, +10

Theranostics

Discovering single nucleotide variants and indels from bulk and single-cell ATAC-seq

Arya R Massarat, Arko Sen, Jeff Jaureguy, +4

Nucleic Acids Research