Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

Zhong Li, Michael Hannigan, Zhicheng Mo, +9

Cell

Signal TransductionMolecular PhysiologySignaling PathwayMolecular PathwayCell Signaling +9

Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

Kewen Hu, Kun Li, Jing Lv, +12

Journal of Clinical Investigation

Chemoprevention StrategySynthetic LethalityCancer BiologyTumor BiologyKras-mutant Lung Adenocarcinoma +14

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

Jian Luo, Zhengfeng Yang, Yu Ma, +16

Nature Medicine

Developmental BiologyBone ResorptionBone Morphogenic ProteinBone RemodelingOsteoarthritis +9

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

Tingfang Yi, Sung‐Gook Cho, Zhengfang Yi, +6

Molecular Cancer Therapeutics

Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation

Asok Mukhopadhyay, Sanjeev Banerjee, Lewis J. Stafford, +3

Oncogene

Tumor BiologySignal TransductionSignaling PathwayCurcumin-induced SuppressionCell Regulation +9

Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

Jiqin Zhang, Yongxian Hu, Jiaxuan Yang, +19

Nature

Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing

Jinyan Li, Dong Zhai, Fang Lv, +7

Acta Biomaterialia

NanotherapeuticsBioactive MetalAntibacterial ActivityWound HealingBiomedical Engineering +3

Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase

Ya‐Chieh Hsu, Joshua J. Chern, Yi Cai, +2

Nature

Drheb GtpaseDevelopmental BiologySignal TransductionSignaling PathwayMolecular Regulation +7

Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Xiaohui Zhang, Biyun Zhu, Liang Chen, +23

Nature Biotechnology

Cellular EnzymologyBiochemistryAdenine Base ConversionsHuman CellsNatural Sciences +9

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB–regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis

Bokyung Sung, Manoj K. Pandey, Kwang Seok Ahn, +4

Blood