Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer

Daisuke Kotani, Eiji Oki, Yoshiaki Nakamura, +19

Nature Medicine

Surgical OncologyOncologyCancer EpidemiologyCancer RiskGastrointestinal Oncology +13

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

Yoshiaki Nakamura, Hiroya Taniguchi, Masafumi Ikeda, +36

Nature Medicine

Scrum-japan Gi-screenOncologyGastrointestinal OncologyTumor HeterogeneityClinical Utility +11

Highly sensitive assay for tyrosine hydroxylase activity by high-performance liquid chromatography

Toshiharu Nagatsu, Kazuhiro Oka, Takeshi Kato

Journal of Chromatography B Biomedical Sciences and Applications

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Circulating tumor DNA-guided treatment with pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer: a phase 2 trial

Yoshiaki Nakamura, Wataru Okamoto, Takeshi Kato, +24

Nature Medicine

Panitumumab vs Bevacizumab Added to Standard First-line Chemotherapy and Overall Survival Among Patients With <i>RAS</i> Wild-type, Left-Sided Metastatic Colorectal Cancer

Jun Watanabe, Kei Muro, Kohei Shitara, +25

JAMA

Modified XELIRI (capecitabine plus irinotecan) versus FOLFIRI (leucovorin, fluorouracil, and irinotecan), both either with or without bevacizumab, as second-line therapy for metastatic colorectal cancer (AXEPT): a multicentre, open-label, randomised, non-inferiority, phase 3 trial

Rui‐Hua Xu, Kei Muro, Satoshi Morita, +17

The Lancet Oncology

MedicinePharmacologyClinical TrialsColorectal CancerMetastatic Colorectal Cancer +8

CIRCULATE‐Japan: Circulating tumor DNA–guided adaptive platform trials to refine adjuvant therapy for colorectal cancer

Hiroya Taniguchi, Yoshiaki Nakamura, Daisuke Kotani, +14

Cancer Science

ctDNA-based molecular residual disease and survival in resectable colorectal cancer

Yoshiaki Nakamura, Jun Watanabe, Naoya Akazawa, +33

Nature Medicine

Interim AnalysisPrognostic BiomarkersSurgical OncologyOncologyCtdna Positivity +12

Blood Perfusion Assessment by Indocyanine Green Fluorescence Imaging for Minimally Invasive Rectal Cancer Surgery (EssentiAL trial)

Jun Watanabe, Ichiro Takemasa, Masanori Kotake, +18

Annals of Surgery

Successive cleavage of N-terminal Arg1-Pro2 and Lys3-Pro4 from substance P but no release of Arg1-Pro2 from bradykinin, by X-Pro dipeptidyl-aminopeptidase

Takeshi Kato, Toshiharu Nagatsu, Katsuhiko Fukasawa, +3

Biochimica et Biophysica Acta (BBA) - Enzymology

Protein ChemistryProtein FunctionBiochemistryProtein FoldingNatural Sciences +8