PBP Active Site Flexibility as the Key Mechanism for β-Lactam Resistance in Pneumococci

Carlos Contreras‐Martel, Cécile Dahout-Gonzalez, Alexandre Martins, +2

Journal of Molecular Biology

Antimicrobial Resistance GeneAntimicrobial SusceptibilityHealth SciencesBiochemistryAntibiotics +10

FtsZ filament capping by MciZ, a developmental regulator of bacterial division

Alexandre W. Bisson‐Filho, Karen Fulan Discola, Patrícia Castellen, +8

Proceedings of the National Academy of Sciences

Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex

Carlos Contreras‐Martel, Alexandre Martins, Chantal Ecobichon, +7

Nature Communications

Protein AssemblyBiochemistryProtein FoldingNatural SciencesBiomolecular Structure Prediction +13

Rational design of ultrastable and reversibly photoswitchable fluorescent proteins for super-resolution imaging of the bacterial periplasm

Mariam El Khatib, Alexandre Martins, Dominique Bourgeois, +2

Scientific Reports

EngineeringProtein AssemblyMicroscopyMolecular BiologySuper-resolution Microscopy +17

Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in <i>Staphylococcus aureus</i> (MRSA)

Carlos Contreras‐Martel, Ana Amoroso, Esther C. Y. Woon, +10

ACS Chemical Biology

EngineeringAntimicrobial ChemotherapyDrug ResistanceAlkyl Boronic AcidsAntibacterial Mechanisms +18

Arginine 66 Controls Dark-State Formation in Green-to-Red Photoconvertible Fluorescent Proteins

Romain Berardozzi, Virgile Adam, Alexandre Martins, +1

Journal of the American Chemical Society

Photoreceptor CellPhotochemistryBiochemistryProtein AssemblyNatural Sciences +13

Characterization of the elongasome core PBP2 : MreC complex of <i>Helicobacter pylori</i>

Meriem El Ghachi, Pierre‐Jean Matteï, Chantal Ecobichon, +10

Molecular Microbiology

Protein AssemblyBiomolecular Structure PredictionStructural BioinformaticsMolecular BiologyAnalytical Ultracentrifugation +16

Trapping of an Acyl–Enzyme Intermediate in a Penicillin-binding Protein (PBP)-catalyzed Reaction

Pauline Machebœuf, David Lemaire, Alexandre Martins, +3

Journal of Molecular Biology

Protein ChemistryBiochemistryNatural SciencesBiocatalysisEnzyme Catalysis +5

Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system

S. Peter Howard, Leandro F. Estrozi, Quentin Bertrand, +7

PLoS Pathogens

Proteinlipid InteractionProtein SecretionProtein AssemblyMolecular BiologyCytoskeleton +15

Self-association of MreC as a regulatory signal in bacterial cell wall elongation

Alexandre Martins, Carlos Contreras‐Martel, Manon Janet-Maitre, +10

Nature Communications