Yong Chen

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Alessia Balestrini, Victory Joseph, Michelle Dourado et al. · The Journal of Experimental Medicine · 2021 · 127 citations · Full text

Inflammation, Asthma, Trpa1 Inhibitor +15

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Jack A. Terrett, Huifen Chen, Daniel G. Shore et al. · Journal of Medicinal Chemistry · 2021 · 49 citations · Full text

Discovery of a Potent (4<i>R</i>,5<i>S</i>)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Huifen Chen, Matthew Volgraf, Steven Do et al. · Journal of Medicinal Chemistry · 2018 · 39 citations · Full text

Drug Target, Molecular Pain, Pharmacotherapy +18

Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease

Jack A. Terrett, Justin Q. Ly, Paula Katavolos et al. · Journal of Medicinal Chemistry · 2024 · 19 citations · Full text

The miRNA-185-5p/STIM1 Axis Regulates the Invasiveness of Nasopharyngeal Carcinoma Cell Lines by Modulating EGFR Activation-Stimulated Switch from E- to N-Cadherin

Yue Luo, Jiaxiang Ye, Yayan Deng et al. · Molecules · 2023 · 11 citations · Full text