Design, synthesis, and biological evaluation of 1,2,4-triazole bearing 5-substituted biphenyl-2-sulfonamide derivatives as potential antihypertensive candidates

Jie Liu, Qin Liu, Xue Yang, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)DerivativesMedicine5-Substituted Biphenyl-2-sulfonamide Derivatives +7

Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease

Hong Yao, Giuseppe Uras, Pengfei Zhang, +11

Journal of Medicinal Chemistry

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation

Shaowen Xie, Feiyan Zhan, Jingjie Zhu, +10

Angewandte Chemie International Edition

Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates

Jinyi Xu, Jingyi Yang, Qian Ran, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceDerivative (Chemistry)MedicineDrug Discovery +6

NLRP3 gene is associated with ulcerative colitis (UC), but not Crohn’s disease (CD), in Chinese Han population

Hongxin Zhang, Zhengting Wang, Xiongxiong Lu, +3

Inflammation Research

InflammationChronic Inflammatory DiseasesNlrp3 GeneMucosal ImmunologyPathogenesis +10

Synthesis and application of ionic liquid functionalized β-cyclodextrin, mono-6-deoxy-6-(4-amino-1,2,4-triazolium)-β-cyclodextrin chloride, as chiral selector in capillary electrophoresis

Jingtang Li, Yu Tao, Guangfu Xu, +6

Journal of Chromatography A

Ionic LiquidEngineeringCapillary ElectrophoresisCyclodextrin ProductionOrganic Chemistry +9

Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain

Wenlong Li, Ying Yin, Shuai Wen, +7

Bioorganic Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryAntiparasitic AgentNatural Sciences +10

Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors

Chaolei Wang, Zheng Wu, Hao Cai, +5

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicine +8

Synthesis and application of amino alcohol-derived chiral ionic liquids, as additives for enantioseparation in capillary electrophoresis

Xiaofei Ma, Yingxiang Du, Xiaodong Sun, +2

Journal of Chromatography A

EngineeringCapillary ElectrophoresisIonic ConductorOrganic ChemistryAnalytical Chemistry +6

Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site

Wenlong Li, Honghao Sun, Feijie Xu, +7

Bioorganic Chemistry

BiochemistryMolecular Properties PredictionMedicineColchicine Binding SiteIndole-vinyl Sulfone Derivatives +8