Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models

Han Chen, Chaolong Wang, Matthew P. Conomos, +13

The American Journal of Human Genetics

Genome-wide Association StudyLinkage DisequilibriumGenotype-phenotype AssociationMedicineGenetics +11

ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies

Yaowu Liu, Sixing Chen, Zilin Li, +3

The American Journal of Human Genetics

Rare-variant AnalysisGeneticsGenetic EpidemiologyPathologyGenomics +15

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

Xihao Li, Zilin Li, Hufeng Zhou, +39

Nature Genetics

Genome-wide Association StudyDynamic IncorporationVariant Association AnalysisAllelic VariantFunctional Genomics +12

Genome sequencing analysis identifies Epstein–Barr virus subtypes associated with high risk of nasopharyngeal carcinoma

Miao Xu, Youyuan Yao, Hui Chen, +28

Nature Genetics

Cancer-associated VirusMedicineImmunologyPathologyVirology +8

FAVOR: functional annotation of variants online resource and annotator for variation across the human genome

Hufeng Zhou, Theodore Arapoglou, Xihao Li, +17

Nucleic Acids Research

Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies

Han Chen, Jennifer E. Huffman, Jennifer A. Brody, +43

The American Journal of Human Genetics

Genome-wide Association StudyAllelic VariantGenotype-phenotype AssociationMedicineGenetics +8

A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

Zilin Li, Xihao Li, Hufeng Zhou, +43

Nature Methods

Genome-wide Association StudySequencingNext-generation SequencingGeneticsStatistical Genetics +9

Test for Rare Variants by Environment Interactions in Sequencing Association Studies

Xinyi Lin, Seunggeun Lee, Michael C. Wu, +4

Biometrics

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, +428

Nature Communications

Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies

Zilin Li, Xihao Li, Yaowu Liu, +6

The American Journal of Human Genetics

Whole-genome Sequencing StudiesGenetic AnalysisAllelic VariantRare-variant Association RegionsSequencing +10