The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

Peichuan Zhang, Barbara C. McGrath, Jamie Reinert, +9

Molecular and Cellular Biology

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)

Bin Zhao, Xin Lin, Lei Li, +4

Journal of Biological Chemistry

BiosynthesisSesquiterpene Antibiotic AlbaflavenoneBiochemistryNatural SciencesSco5222 Gene +11

CRISPR-Cpf1-Assisted Multiplex Genome Editing and Transcriptional Repression in Streptomyces

Lei Li, Keke Wei, Guosong Zheng, +4

Applied and Environmental Microbiology

Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes

Lei Li, Guosong Zheng, Jun Chen, +3

Metabolic Engineering

EngineeringBiotechnologySynthetic BiologySynthetic CircuitNatural Product Biosynthesis +8

Characterization of the Saframycin A Gene Cluster from<i>Streptomyces lavendulae</i>NRRL 11002 Revealing a Nonribosomal Peptide Synthetase System for Assembling the Unusual Tetrapeptidyl Skeleton in an Iterative Manner

Lei Li, Wei Deng, Jie Song, +6

Journal of Bacteriology

Tetrahydroisoquinoline BiosynthesisActive AnalogsCombinatorial BiosynthesisMolecular BiologyChemical Biology +15

Functional Analysis of the Validamycin Biosynthetic Gene Cluster and Engineered Production of Validoxylamine A

Linquan Bai, Lei Li, Hui Xu, +7

Chemistry & Biology

Engineered ProductionBiosynthesisEngineeringBiochemistryNatural Sciences +11

CRISPR/dCas9‐Mediated Multiplex Gene Repression in <i>Streptomyces</i>

Yawei Zhao, Lei Li, Guosong Zheng, +4

Biotechnology Journal

EngineeringMolecular BiologyEscherichia ColiMultiplex Gene RepressionNovel Crispri System +16

Generation and Characterization of a Cyp2f2-Null Mouse and Studies on the Role of CYP2F2 in Naphthalene-Induced Toxicity in the Lung and Nasal Olfactory Mucosa

Lei Li, Yuan Wei, Laura S. Van Winkle, +6

Journal of Pharmacology and Experimental Therapeutics

Gene Cluster Responsible for Validamycin Biosynthesis in <i>Streptomyces hygroscopicus</i> subsp. <i>jinggangensis</i> 5008

Yi Yu, Linquan Bai, Kazuyuki Minagawa, +9

Applied and Environmental Microbiology

Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

Bin Zhao, Lei Li, Dmitry G. Vassylyev, +6

Journal of Biological Chemistry

Crystal StructureBiosynthesisAldehyde DehydrogenaseBiochemistryNatural Sciences +13