A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Xiangyang Chi, Renhong Yan, Jun Zhang

Science

Spike ProteinFull SpikeVaccine TargetN-terminal DomainViral Pathogenesis +13

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

Fengcai Zhu, Xu-Hua Guan, Yu-Hua Li, +24

The Lancet

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

Ke Wang, Wei Chen, Zheng Zhang, +42

Signal Transduction and Targeted Therapy

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

Ke Wang, Wei Chen, Yusen Zhou, +27

Cd147-spike ProteinViral DiagnosticsViral PathogenesisImmunologyImmunodominance +16

Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR

Jun Zhang, Wendong Huang, Steven S. Chua, +2

Science

Xenobiotic Receptor CarHealth SciencesBiochemistryPharmacological StudyMedicine +11

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

Shipo Wu, Jianying Huang, Zhe Zhang, +16

The Lancet Infectious Diseases

A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

Shipo Wu, Gongxun Zhong, Jun Zhang, +22

Nature Communications

Functional Proteomic Analysis of Protein Kinase C ε Signaling Complexes in the Normal Heart and During Cardioprotection

Peipei Ping, Jun Zhang, William M. Pierce, +1

Circulation Research

Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR

Wendong Huang, Jun Zhang, Ping Wei, +2

Molecular Endocrinology

BiochemistryFunctional SelectivityMedicineImmunologyAgonist Ligand +11

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma

Jiejie Geng, Liang Chen, Yufeng Yuan, +44

Signal Transduction and Targeted Therapy

Universal ReceptorHumoral ResponseImmunologyImmunodominanceImmunologic Mechanism +17