A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Xiangyang Chi, Renhong Yan, Jun Zhang

Science

Spike ProteinFull SpikeVaccine TargetN-terminal DomainViral Pathogenesis +13

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

Xiangyang Chi, Renhong Yan, Jun Zhang, +21

New Vulnerable EpitopeViral PathogenesisImmunologyImmunodominanceMolecular Biology +16

Enterovirus 71 Inhibits Cellular Type I Interferon Signaling by Downregulating JAK1 Protein Expression

Ying Liu, Zhe Zhang, Xinghui Zhao, +10

Viral Immunology

Molecular VirologyInhibits Cellular TypePathogenesisViral PathogenesisImmunology +13

Tetanus Neurotoxin Neutralizing Antibodies Screened from a Human Immune scFv Antibody Phage Display Library

Han Wang, Rui Yu, Ting Fang, +7

Toxins

VaccinationAllergyTent Intoxication TherapyMedicineImmunology +12

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration

Huan Ma, Xinghai Zhang, Weihong Zeng, +16

Cell Discovery

Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunization

Qiqi Cao, Shipo Wu, Chuan‐Le Xiao, +13

Cell Discovery

Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors

Pengfei Fan, Xiangyang Chi, Guodong Liu, +10

mAbs

VaccinationVaccine DevelopmentAllergyMonoclonal Antibody 2G1Vaccine Target +12

Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

Xiangyang Chi, Yingying Guo, Guanying Zhang, +26

Signal Transduction and Targeted Therapy

Developing Pseudovirus-Based Neutralization Assay against Omicron-Included SARS-CoV-2 Variants

Hancong Sun, Jinghan Xu, Guanying Zhang, +6

Viruses

Global SpreadViral EvolutionViral DiagnosticsPseudovirus-based Neutralization AssayPseudovirus Neutralization Assay +8

Generation and Characterization of Human Monoclonal Antibodies Targeting Anthrax Protective Antigen following Vaccination with a Recombinant Protective Antigen Vaccine

Xiangyang Chi, Jianmin Li, Weicen Liu, +13

Clinical and Vaccine Immunology