The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity

Donald E. Pryor, Aurora O’Brate, Geoffrey Bilcer, +9

Biochemistry

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Rui Xiong, Leike Zhang, Shiliang Li, +22

Protein & Cell

Phase separation of EB1 guides microtubule plus-end dynamics

Xiaoyu Song, Fengrui Yang, Tongtong Yang, +22

Nature Cell Biology

Biophysical ModelingCell DivisionMolecular BiologyCytoskeletonProtein Phase Separation +3

Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis

Xiaoyu Song, Fengrui Yang, Xu Liu, +22

Nature Chemical Biology

ChromatinSpindle PositioningCell DivisionMacromolecular MachineDynamic Crotonylation +7

Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates

Yong Wang, Jingming Zhang, Boyang Han, +12

Nature Communications

A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice

Xun Liu, Zejiao Da, Yue Wang, +9

Vaccine

VaccinationMucosal VaccinationCross-protectionVaccine DevelopmentVaccine Research +9

Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast

Yue Shen, Feng Gao, Yun Wang, +28

Cell Genomics

M. tuberculosis H37Rv Infection of Chinese Rhesus Macaques

Jing Zhang, Yanqing Ye, Yong Wang, +12

Journal of Neuroimmune Pharmacology

Chinese Rhesus MacaquesImmunologyVirologyTuberculosisMedicine +1

Hepatitis C Virus-Induced FUT8 Causes 5-FU Drug Resistance in Human Hepatoma Huh7.5.1 Cells

Shu Li, Xiaoyu Liu, Qiu Pan, +5

Viruses

Hepatitis C VirusPathologyImmunotherapeuticsAutoimmune Liver DiseaseDrug Resistance +15

IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization

Yanping Luo, Xingming Ma, Xun Liu, +8

International Immunology