Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits

Shu‐Sheng Jiao, Xiu‐Qing Yao, Yu-Hui Liu, +24

Proceedings of the National Academy of Sciences

Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy

Chuanbin Yang, Cheng-Fu Su, Ashok Iyaswamy, +13

Acta Pharmaceutica Sinica B

U0126 attenuates ischemia/reperfusion-induced apoptosis and autophagy in myocardium through MEK/ERK/EGR-1 pathway

Anxing Wang, Huijun Zhang, Zeming Liang, +9

European Journal of Pharmacology

Cardiac MuscleMitophagyCell AutophagyMolecular PhysiologySignal Transduction +13

Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models

Ashok Iyaswamy, Xueli Wang, Senthilkumar Krishnamoorthi, +14

Redox Biology

EngineeringNeurochemical BiomarkersAmyloid Precursor ProteinSynaptic SignalingNeuroinflammation +22

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, +13

Phytomedicine

Hdac6 InhibitionProteasomal DegradationAlzheimer's DiseaseMedicineDementia +10

A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro

Ziying Wang, Chuanbin Yang, Jia Liu, +10

International Journal of Molecular Sciences

Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer's disease share immunoreactivity for amyloid precursor protein, Aβ, α1-antichymotrypsin and ubiquitin-protein conjugates

Yue Huang, Mary M. Herman, Jia Liu, +3

Brain Research

Experimental Aluminum-induced EncephalopathyNeurodegenerative DiseasesAlzheimer's DiseaseBiochemistryExperimental Neuropathology +10

Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: Regulation by a polyphenol -(−)-epigallocatechin-3-gallate

Jia Liu, Ying Tang, Zhihui Feng, +8

Metabolism

Cell AutophagySystems BiologyMolecular PhysiologyH9c2 CardiomyoblastsAutophagy +11

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Benjamin Chun‐Kit Tong, Aston Jiaxi Wu, Shiying Huang, +14

Autophagy

Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease

Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Huan Zhang, +10

Phytomedicine

Neurodegenerative DiseasesAlzheimer's DiseaseMolecular NeurosciencePparα-tfeb ActivationDegenerative Pathology +10