Chunhui Zhang

Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations

Chunhui Zhang, Elizabeth A. Stone, M.G. Deshmukh et al. · ACS Central Science · 2021 · 259 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2

Mohammad Mehdi Ghahremanpour, Julian Tirado‐Rives, M.G. Deshmukh et al. · ACS Medicinal Chemistry Letters · 2020 · 220 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

M.G. Deshmukh, Joseph A. Ippolito, Chunhui Zhang et al. · Structure · 2021 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

miR-15b-5p resensitizes colon cancer cells to 5-fluorouracil by promoting apoptosis via the NF-κB/XIAP axis

Ci Zhao, Qi Zhao, Chunhui Zhang et al. · Scientific Reports · 2017 · 59 citations · Full text

Medicine, Oncology, Pharmacology +17

Structural Optimization and Structure–Activity Relationships of <i>N</i>²-(4-(4-Methylpiperazin-1-yl)phenyl)-<i>N</i>⁸-phenyl-9<i>H</i>-purine-2,8-diamine Derivatives, a New Class of Reversible Kinase Inhibitors Targeting both EGFR-Activating and Resistance Mutations

Jiao Yang, Lijiao Wang, Jingjing Liu et al. · Journal of Medicinal Chemistry · 2012 · 57 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15