Lijiao Wang

Structure–Activity Relationship Studies of Pyrazolo[3,4-<i>d</i>]pyrimidine Derivatives Leading to the Discovery of a Novel Multikinase Inhibitor That Potently Inhibits FLT3 and VEGFR2 and Evaluation of Its Activity against Acute Myeloid Leukemia in Vitro and in Vivo

Lingling Yang, Guo‐Bo Li, Shuang Ma et al. · Journal of Medicinal Chemistry · 2013 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structural Optimization and Structure–Activity Relationships of <i>N</i>²-(4-(4-Methylpiperazin-1-yl)phenyl)-<i>N</i>⁸-phenyl-9<i>H</i>-purine-2,8-diamine Derivatives, a New Class of Reversible Kinase Inhibitors Targeting both EGFR-Activating and Resistance Mutations

Jiao Yang, Lijiao Wang, Jingjing Liu et al. · Journal of Medicinal Chemistry · 2012 · 57 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Anticancer effect of Polyphyllin Ι in colorectal cancer cells through ROS-dependent autophagy and G2/M arrest mechanisms

Si Yu, Lijiao Wang, Zhixing Cao et al. · Natural Product Research · 2017 · 42 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Discovery of the Novel Potent and Selective FLT3 Inhibitor 1-{5-[7-(3- Morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-<i>p</i>-tolylurea and Its Anti-Acute Myeloid Leukemia (AML) Activities <i>in Vitro</i> and <i>in Vivo</i>

Weiwei Li, Xiaoyan Wang, Renlin Zheng et al. · Journal of Medicinal Chemistry · 2012 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Drug Discovery against Psoriasis: Identification of a New Potent FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor, 1-(4-((1<i>H</i>-Pyrazolo[3,4-<i>d</i>]pyrimidin-4-yl)oxy)-3-fluorophenyl)-3-(5-(<i>tert</i>-butyl)isoxazol-3-yl)urea, That Showed Potent Activity in a Psoriatic Animal Model

Guo‐Bo Li, Shuang Ma, Lingling Yang et al. · Journal of Medicinal Chemistry · 2016 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14