Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

Min Hu, Pingwei Li, Muyang Li, +6

Cell

Crystal StructureAldehyde DehydrogenaseBiochemistryNatural SciencesProtein X-ray Crystallography +5

Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome

Le Wang, Hongliang Cong, Jingxia Zhang, +9

Cardiovascular Diabetology

Structure of the apoptotic protease-activating factor 1 bound to ADP

Stefan J. Riedl, Wenyu Li, Chao Yang, +2

Nature

Protein FunctionSignal TransductionBiochemistryNatural SciencesApoptosis +8

Single-Stranded siRNAs Activate RNAi in Animals

Walt F. Lima, Thazha P. Prakash, Heather Murray, +9

Cell

Natural SciencesRna BiologyMolecular BiologySmall RnaGene Expression +1

Structural Mechanism of Smad4 Recognition by the Nuclear Oncoprotein Ski

Jia-Wei Wu, Ariel R. Krawitz, Jijie Chai, +4

Cell

Protein FunctionProtein AssemblySmad4 RecognitionNatural SciencesMedicine +5

Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase

Qun Dang, Yan Liu, Daniel K. Cashion, +15

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ScienceBiochemistryHuman Liver FbpaseMedicine +12

TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage

Pengfei Xu, Chunrong Tao, Yuyou Zhu, +10

Journal of Neuroinflammation

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination

Jijie Chai, Nieng Yan, Jun R. Huh, +4

Nature Structural & Molecular Biology

Protein FunctionSignal TransductionMolecular RegulationNatural SciencesMolecular Biology +5

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim

Nieng Yan, Jia-Wei Wu, Jijie Chai, +2

Nature Structural & Molecular Biology

Drice InhibitionBiochemistryMedicinePharmacologyMolecular Mechanisms +1

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

Thazha P. Prakash, Walt F. Lima, Heather Murray, +8

Nucleic Acids Research