Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

Kulandaivelu S. Vetrivel, Haipeng Cheng, William Lin, +6

Journal of Biological Chemistry

Proteinlipid InteractionProtein SecretionCytoskeletonAmyloid Precursor ProteinCellular Physiology +16

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties

Vasiliki Mahairaki, Jiwon Ryu, Ann Peters, +9

Stem Cells and Development

Cerebral OrganoidNeurochemical BiomarkersHipsc-derived NeuronsStem Cell BiologySocial Sciences +24

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer’s disease mouse model

Tong Li, Kerstin E. Braunstein, Juhong Zhang, +4

Nature Communications

CP1 Domain in <i>Escherichia coli </i>Leucyl-tRNA Synthetase Is Crucial for Its Editing Function

Jian-Feng Chen, Ni-ni Guo, Tong Li, +2

Biochemistry

EngineeringMolecular BiologyEscherichia ColiProtein SynthesisBiosynthesis +14

Glu332 in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity

Lucía Chávez‐Gutiérrez, Alexandra Tolia, Elke Maes, +3

Journal of Biological Chemistry

Protein SecretionMolecular BiologyComplex MaturationCellular PhysiologySecretory Granules +15

Investigation of the contribution of total creatine to the CEST <i>Z</i>‐spectrum of brain using a knockout mouse model

Lin Chen, Haifeng Zeng, Xiang Xu, +8

NMR in Biomedicine

Brain DevelopmentNeuromodulation TherapiesNeurophysiological BiomarkersBrain ScienceClinical Neuroscience +23

Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm

Martin Picard, Ilan Azuelos, Boris Jung, +10

Journal of Applied Physiology

MitophagyMitochondrial DysfunctionCytoskeletonAnatomyCellular Physiology +16

Assessment of the Phenolic Profiles, Hypoglycemic Activity, and Molecular Mechanism of Different Highland Barley (Hordeum vulgare L.) Varieties

Na Deng, Bisheng Zheng, Tong Li, +1

International Journal of Molecular Sciences

NutritionGlycobiologyAgricultural EconomicsGrain QualityDifferent Highland Barley +21

Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease

Anabel Gonzalez-Gil, Ryan N. Porell, Steve M. Fernandes, +11

Journal of Biological Chemistry

Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Tong Li, Hongjin Wen, Cory Brayton, +9

Journal of Neuroscience