Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

Xiao Xiao, Jing Li, R. Jude Samulski

Journal of Virology

Muscle TissueAdeno-associated Virus VectorViral ReplicationEngineeringIn Vivo Gene Therapy +15

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

Yapeng Su, Daniel Chen, Dan Yuan, +51

Cell

Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

Xindong Liu, Yun Wang, Huiping Lu, +26

Nature

Signal TransductionAutoimmune DiseaseT Cell DysfunctionT-regulatory CellImmunology +6

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

Young‐Hee Lee, Natalia Martín‐Orozco, Peilin Zheng, +23

Cell Research

Lymphoid NeoplasiaCytotoxic Lymphocyte FunctionImmunologyImmune Checkpoint InhibitorImmunotherapy +5

Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer

Gulidanna Shayan, Raghvendra M. Srivastava, Jing Li, +2

OncoImmunology

Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients

Jie Hb, Neil Gildener‐Leapman, Jing Li, +4

British Journal of Cancer

PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer

Benjamin Kansy, Fernando Concha‐Benavente, Raghvendra M. Srivastava, +13

Cancer Research

PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment

Jing Li, Hyun-Bae Jie, Yu L. Lei, +3

Cancer Research

ImmunologyImmune RegulationImmunodominanceIfnγ SecretionImmunoediting +20

KIR ⁺ CD8 ⁺ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Jing Li, Maxim Zaslavsky, Yapeng Su, +32

Science

High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells

Jing Li, Yi He, Jing Hao, +2

Frontiers in Immunology