TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Yingjun Zhao, Xilin Wu, Xiaoguang Li, +13

Neuron

Neurodegenerative DiseasesMicroglial FunctionMedicineImmunologyDegenerative Pathology +4

Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion

Xiujie Sun, Bogang Wu, Huai-Chin Chiang, +28

Nature

Tumor BiologyMedicineImmunologyImmunoeditingPathology +8

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

Kai Sun, Jiyoung Park, Olga T. Gupta, +10

Nature Communications

ObesityMetabolic SyndromeBody CompositionMetabolic DisorderEndotrophin Triggers +8

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

Shangang Zhao, Yi Zhu, Robbie D. Schultz, +22

Cell Metabolism

NutritionInsulin SignalingGastrointestinal Peptide HormoneObesityMetabolic Syndrome +14

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

Mi Deng, Xun Gui, Jaehyup Kim, +43

Nature

Cancer ImmunosurveillanceT Cell SuppressionImmunologyCellular Immune ResponseTumour Infiltration +7

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

Chisato M. Yamazaki, Aiko Yamaguchi, Yasuaki Anami, +7

Nature Communications

Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice

Yasuaki Anami, Chisato M. Yamazaki, Wei Xiong, +4

Nature Communications

Trastuzumab Triggers Phagocytic Killing of High HER2 Cancer Cells In Vitro and In Vivo by Interaction with Fcγ Receptors on Macrophages

Yun Shi, Xuejun Fan, Hui Deng, +7

The Journal of Immunology

ImmunologyImmune RegulationCell DeathImmunoeditingImmunologic Mechanism +19

Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants

Zhiqiang Ku, Xuping Xie, Paul R. Hinton, +22

Nature

VaccinationMucosal VaccinationSars-cov-2 VariantsVaccine TargetImmunology +5

Antibody therapies for the prevention and treatment of viral infections

Georgina To’a Salazar, Ningyan Zhang, Tong‐Ming Fu, +1

npj Vaccines