23:T4ce,Endometrial cancer (EC) is a common malignancy of the female reproductive system, with an escalating incidence. Recurrent/metastatic EC presents a poor prognosis. The interaction between the long non-coding RNA (lncRNA) HOTAIR and the polycomb repressive complex 2 (PRC2) induces abnormal silencing of tumor suppressor genes, exerting a pivotal role in tumorigenesis. We have previously discovered AC1Q3QWB (AQB), a small-molecule compound targeting HOTAIR-EZH2 interaction. In the present study, we unveil that AQB selectively hampers the interaction between HOTAIR and EZH2 within EC cells, thus reversing the epigenetic suppression of tumor suppressor genes. Furthermore, our findings demonstrate AQB's synergistic effect with tazemetostat (TAZ), an EZH2 inhibitor, significantly boosting the expression of CDKN1A and SOX17. This, in turn, induces cell cycle arrest and impedes EC cell proliferation, migration, and invasion. In vivo experiments further validate AQB's potential by enhancing TAZ's anti-tumor efficacy at lower doses. Our results advocate AQB, a recently discovered small-molecule inhibitor, as a promising agent against EC cells. When combined with TAZ, it offers a novel therapeutic strategy for EC treatment.24:T482,Rational design of electrode materials with an excellent structure and morphology is crucial for improving electrochemical properties. Herein, various unique nanostructured Bi₂S₃ materials with controllable morphology were obtained through a simple and efficient oil bath reaction strategy. Bi₂S₃ with different morphologies can be obtained by regulating the polarity of solvent, and the lattice spacing can also be adjusted. The Bi₂S₃ nanomaterials obtained with ethanol as solvent (BS-3) show a three-dimensional nanoflower-like structure assembled with porous layers. The unique structure facilitates the transport of ions and accommodates the volume variation of Bi₂S₃ during energy storage. Consequently, BS-3 nanoflowers exhibited superior cycling stability and excellent high-rate capability for lithium storage (maintained a high capacity of 923.8 mA h g^-1 after 950 cycles at 1.0 A g^-1) and excellent sodium storage. We provide guidance for precise synthesis and energy storage application of Bi₂S₃ nanomaterials.

#	Concept	H-Index	Publications	Citations
1	Medicine	4	4	81
2	Engineering	2	2	30
3	Public Health	1	1	13
4	Biochemistry	1	1	34
5	Cell Biology	1	1	16

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