Concepedia

Karena Last

KL

Statistics

Publications

33

Citations

3.5K

H-Index

25

Active since

1991

Affiliations

The University of Melbourne(Current)

Royal Children's Hospital

Murdoch Children's Research Institute

The Royal Melbourne Hospital

Shriners Hospitals for Children - Tampa

Karena Last is an author at The University of Melbourne specializing in life sciences, molecular biology, and aggrecan biology.

ORCID

Publications per year

1991–2025

33

Publications

33

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East et al. · Nature · 2005 · 915 citations

, , +14

Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13)

Amanda Fosang, Karena Last, Vera Knäuper et al. · FEBS Letters · 1996 · 376 citations · Full text

, , +15

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

Amanda Fosang, Peter J. Neame, Karena Last et al. · Journal of Biological Chemistry · 1992 · 297 citations · Full text

, , +16

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.

Amanda Fosang, Karena Last, Rose A. Maciewicz · Journal of Clinical Investigation · 1996 · 201 citations · Full text

, , +15

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

Amanda Fosang, Karena Last, Vera Knäuper et al. · Biochemical Journal · 1993 · 161 citations · Full text

, , +12

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