Karena Last

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East et al. · Nature · 2005 · 905 citations

Regenerative Medicine, Major Aggrecanase, Developmental Biology +10

Degradation of cartilage aggrecan by collagenase‐3 (MMP‐13)

Amanda Fosang, Karena Last, Vera Knäuper et al. · FEBS Letters · 1996 · 376 citations · Full text

Mmp Family, Immunology, Pathology +17

The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.

Amanda Fosang, Peter J. Neame, Karena Last et al. · Journal of Biological Chemistry · 1992 · 297 citations · Full text

Amino Acids, Pathology, Chemical Biology +21

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.

Amanda Fosang, Karena Last, Rose A. Maciewicz · Journal of Clinical Investigation · 1996 · 201 citations · Full text

Mmp-8 Digest, Immunology, Pathology +21

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

Amanda Fosang, Karena Last, Vera Knäuper et al. · Biochemical Journal · 1993 · 161 citations · Full text

Pathology, Bone Morphogenic Protein, Collagenase Catalytic Fragments +16