Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated <i>In Vitro</i> and with Clinical Specimens

Jasper Fuk‐Woo Chan, Cyril Chik‐Yan Yip, Kelvin Kai‐Wang To, +13

Journal of Clinical Microbiology

Structure-based discovery of clinically approved drugs as Zika virus NS2B-NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo

Shuofeng Yuan, Jasper Fuk‐Woo Chan, Helena den-Haan, +15

Antiviral Research

Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens

Cyril Chik‐Yan Yip, Chi-Chun Ho, Jasper Fuk‐Woo Chan, +15

International Journal of Molecular Sciences

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy

Jasper Fuk‐Woo Chan, Zheng Zhu, Hin Chu, +12

Antiviral Research

ImmunologyHost-targeting Treatment StrategyCell DeathVirologyAntiviral Drug Development +6

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells

Bingpeng Yan, Zijiao Zou, Hin Chu, +11

International Journal of Molecular Sciences

Molecular VirologyViral PersistenceFatty AcidsVirus InfectionPathogenesis +11

Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway

Bingpeng Yan, Shuofeng Yuan, Jianli Cao, +23

International Journal of Biological Sciences

Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses

Jessica Oi‐Ling Tsang, Jie Zhou, Xiaoyu Zhao, +7

Biomedicines

Viral ReplicationMolecular VirologyPhysiologically Relevant ModelNeurovirologyPathogenesis +12

Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters

Jasper Fuk‐Woo Chan, Vincent Kwok‐Man Poon, Chris Chung Sing Chan, +24

Clinical Infectious Diseases

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

Zijiao Zou, Jessica Oi‐Ling Tsang, Bingpeng Yan, +11

Metabolites

Metastasis suppressor 1 regulates neurite outgrowth in primary neuron cultures

Juan Yu, Shuyun Lin, Mei Wang, +6

Neuroscience

Developmental BiologyCell RegulationCell ProliferationPrimary Neuron CulturesMedicine +2