Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Ignazio Caruana, Barbara Savoldo, Valentina Hoyos, +5

Nature Medicine

Tumor BiologyTumor InfiltrationAntitumor ActivityCancer ImmunosurveillanceImmunology +7

The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia

Rayne H. Rouce, Hila Shaim, Takuya Sekine, +11

Leukemia

Hematological MalignancyCancer ImmunosurveillanceImmune RegulationImmunologyHematology +5

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

Concetta Quintarelli, Domenico Orlando, Iolanda Boffa, +14

OncoImmunology

Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant

Gerrit Weber, Ulrike Gerdemann, Ignazio Caruana, +8

Leukemia

Cell TherapyTransplantationMarrow TransplantationStem Cell TransplantationImmunology +8

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis

Juliane Becher, Luca Simula, Elisabetta Volpe, +28

Developmental Cell

Developmental BiologySignal TransductionT-regulatory CellGene RegulationCellular Regulatory Mechanism +8

Generation of Tumor Antigen-Specific T Cell Lines from Pediatric Patients with Acute Lymphoblastic Leukemia—Implications for Immunotherapy

Gerrit Weber, Ignazio Caruana, Rayne H. Rouce, +5

Clinical Cancer Research

Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation

Pietro Merli, Ignazio Caruana, Rita De Vito, +16

Haematologica

Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant

Emmanuel de Billy, Marsha Pellegrino, Domenico Orlando, +25

Neuro-Oncology

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation

Selim Kuçi, Eva Rettinger, B Voss, +9

Haematologica

Standardization of WT1 mRNA quantitation for minimal residual disease monitoring in childhood AML and implications of WT1 gene mutations: a European multicenter study

André Willasch, Bernd Gruhn, Tiziana Coliva, +13

Leukemia

Genetic DisorderMedicineGeneticsPathologyChildhood Aml +9