Sonja Hager

Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH

Enrico Falcone, Alessandra Gilda Ritacca, Sonja Hager et al. · Journal of the American Chemical Society · 2022 · 76 citations · Full text

Life Sciences, Biochemistry, Cancer Biology +16

The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

Sonja Hager, Katharina Korbula, Bjoern Bielec et al. · Cell Death and Disease · 2018 · 74 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13

Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling

Zhengnan Cai, Li Wan, Sonja Hager et al. · Cellular and Molecular Immunology · 2024 · 72 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

Structure–Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

Philipp Fronik, Isabella Poetsch, Alexander Kastner et al. · Journal of Medicinal Chemistry · 2021 · 62 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

Julia H. Bormio Nunes, Sonja Hager, Marlene Mathuber et al. · Journal of Medicinal Chemistry · 2020 · 56 citations · Full text

Medicine, Oncology, Pharmacology +15