Barbara Roth

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogs with high activity and specificity for bacterial dihydrofolate reductase

Jay V. Johnson, Barbara S. Rauckman, David P. Baccanari et al. · Journal of Medicinal Chemistry · 1989 · 208 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

A A Miller, P L Wheatley, David A. Sawyer et al. · Epilepsia · 1986 · 184 citations

Medicine, Pharmacology, Pharmacotherapy +13

5-Benzyl-2,4-diaminopyrimidines as Antibacterial Agents. I. Synthesis and Antibacterial Activity <i>in vitro</i>

Barbara Roth, Elvira A. Falco, George H. Hitchings et al. · Journal of Medicinal Chemistry · 1962 · 129 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs

Lee F. Kuyper, Barbara Roth, David P. Baccanari et al. · Journal of Medicinal Chemistry · 1985 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Protonation of 2,4-diaminopyrimidines. I. Dissociation constants and substituent effects

Barbara Roth, Justina Z. Strelitz · The Journal of Organic Chemistry · 1969 · 89 citations

Natural Sciences, Chemistry, Medicinal Chemistry +11