James R. Birtley

Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions

Zoltán Bozóky, Mickaël Krzeminski, Ranjith Muhandiram et al. · Proceedings of the National Academy of Sciences · 2013 · 171 citations

Life Sciences, Biochemistry, Molecular Biology +17

Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease

James R. Birtley, Stephen R. Knox, Agnès M. Jaulent et al. · Journal of Biological Chemistry · 2005 · 148 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

Efthalia Zervoudi, Emmanuel Saridakis, James R. Birtley et al. · Proceedings of the National Academy of Sciences · 2013 · 128 citations · Full text

Life Sciences, Immunology, Oncology +15

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

Irini Evnouchidou, James R. Birtley, Sergey S. Seregin et al. · The Journal of Immunology · 2012 · 104 citations · Full text

Life Sciences, Genetics, Immunology +17

The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing

James R. Birtley, Emmanuel Saridakis, Efstratios Stratikos et al. · Biochemistry · 2011 · 103 citations

Life Sciences, Biochemistry, Molecular Biology +17