Jian-Tao Shi

Discovery of novel VEGFR-2-PROTAC degraders based on the localization of lysine residues via recruiting VHL for the treatment of gastric cancer

Xingrong Wang, Shuai Wang, Hong-Xia Mu et al. · European Journal of Medicinal Chemistry · 2022 · 19 citations · Full text

Medicine, Molecular Biology, Oncology +8

Design, synthesis and biological evaluation of novel pyrazinone derivatives as PI3K/HDAC dual inhibitors

Zi-Xiao Wang, Shuai Wang, Xue-Peng Qiao et al. · Bioorganic & Medicinal Chemistry · 2022 · 17 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

1H-Indazoles derivatives targeting PI3K/AKT/mTOR pathway: Synthesis, anti-tumor effect and molecular mechanism

Shuai Wang, Jian-Tao Shi, Xingrong Wang et al. · Bioorganic Chemistry · 2023 · 17 citations

Medicine, Oncology, Pharmacology +17

Design, synthesis, and biological evaluation of quinoxalinone derivatives as potent BRD4 inhibitors

Kai-Yan Xu, Xueting Wang, Lei Cheng et al. · Bioorganic & Medicinal Chemistry · 2022 · 14 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Design, synthesis and biological evaluation of coumarin derivatives as potential BRD4 inhibitors

Qi-Hang Cui, Wenbo Li, Zhaoyang Wang et al. · Bioorganic Chemistry · 2022 · 11 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9