Elena Friedmann

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production

Elena Friedmann, Ehud Hauben, Kerstin Maylandt et al. · Nature Cell Biology · 2006 · 196 citations

Inflammation, Cytokine, Signal Transduction +11

A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b

Regina Fluhrer, Gudula Grammer, Lars Israel et al. · Nature Cell Biology · 2006 · 134 citations · Full text

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

Vladimir Kirkin, Nathalie Cahuzac, Francisca Guardiola-Serrano et al. · Cell Death and Differentiation · 2007 · 131 citations · Full text

Sppl2a Cleavage, Signal Transduction, Signaling Pathway +10

Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors

Andreas Weihofen, Marius K. Lemberg, Elena Friedmann et al. · Journal of Biological Chemistry · 2003 · 125 citations · Full text

Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins

Elena Friedmann, Marius K. Lemberg, Andreas Weihofen et al. · Journal of Biological Chemistry · 2004 · 105 citations · Full text