Translocation of a gut pathobiont drives autoimmunity in mice and humans

Sílvio M. Vieira, Michael Hiltensperger, Varun Kumar, +14

Science

Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe

Takeshi Mizuguchi, Geoffrey Fudenberg, Sameet Mehta, +8

Nature

Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner

Dimple Notani, Kamalvishnu Gottimukkala, Ranveer Singh Jayani, +6

PLoS Biology

Wnt SignallingMolecular RegulationEpigeneticsConserved WntTranscriptional Regulation +16

Mtr4-like Protein Coordinates Nuclear RNA Processing for Heterochromatin Assembly and for Telomere Maintenance

Nathan N. Lee, Venkata R. Chalamcharla, Francisca E. Reyes‐Turcu, +8

Cell

ChromatinChromatin StructureChromatin RemodelingNatural SciencesGenetics +8

RNAi triggered by specialized machinery silences developmental genes and retrotransposons

Soichiro Yamanaka, Sameet Mehta, Francisca E. Reyes‐Turcu, +5

Nature

Developmental BiologyGeneticsRna BiologyGene RegulationMolecular Genetics +6

MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3

Mugdha V. Joglekar, Vishal S. Parekh, Sameet Mehta, +2

Developmental Biology

Microrna ProfilingTranscriptional RegulationFunctional GenomicsDevelopmental BiologyNeurogenomics +7

Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response

Mahnaz Sahraei, Balkrishna Chaube, Yuting Liu, +14

Journal of Clinical Investigation

Tumor-associated MacrophagesImmunologyBiological MicroenvironmentsPathologyImmunoediting +17

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin

Ozan Aygün, Sameet Mehta, Shiv I. S. Grewal

Nature Structural & Molecular Biology

Histone ModificationsChromatinHistone TurnoverChromatin StructureChromatin Remodeling +13

Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV

Shelli Farhadian, Sameet Mehta, Chrysoula Zografou, +6

JCI Insight

Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target

Runxia Liu, Yang-Hui Jimmy Yeh, Ales Varabyou, +21

Science Translational Medicine