21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T4d4,Coenzyme Q₁₀ (CoQ₁₀) is widely used in preventive or curative treatment of cardiovascular diseases. However, CoQ₁₀ exhibits an extremely low solubility in aqueous medium as well as a poor oral bioavailability. Therefore, solanesyl poly(ethylene glycol) succinate (SPGS) and CoQ₁₀ were formulated as CoQ₁₀-SPGS micelles with a high content of CoQ₁₀ to improve the bioavailability of CoQ₁₀ in rat. Findings indicate that, in the CoQ₁₀-SPGS micelles, SPGS is self-assembled into stable nanosized micelles with a CoQ₁₀ loading capacity of more than 39%. The CoQ₁₀-SPGS micelles exhibit an enhanced photostability upon exposure to simulated sunlight. In vivo experiments demonstrate that, as compared to that of the coarse suspensions of CoQ₁₀, there was three-fold enhancement of oral bioavailability for CoQ₁₀-loaded SPGS micelles depending on varying molecular weight of SPGS. In the encapsulation of CoQ₁₀ by SPGS micelles, the self-assembled nanocarriers with strong muco-adhesive properties lead to increases in the solubility and oral absorption of lipophilic CoQ₁₀ nanoparticles.

#	Concept	H-Index	Publications	Citations
1	Engineering	1	1	39
2	Natural Sciences	1	1	39
3	Chemistry	1	1	39
4	Pharmacology	1	1	39
5	Medicinal Chemistry	1	1	39

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