James Berstler

Small-molecule WNK inhibition regulates cardiovascular and renal function

Ken Yamada, Hyi-Man Park, Dean F. Rigel et al. · Nature Chemical Biology · 2016 · 167 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +10

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

Srinivas Niranj Chandrasekaran, Beth A. Cimini, Amy Goodale et al. · Nature Methods · 2024 · 122 citations · Full text

Life Sciences, Bioinformatics, Cell Biology +13

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells

Liv Johannessen, Thomas B. Sundberg, Daniel J. O’Connell et al. · Nature Chemical Biology · 2017 · 69 citations · Full text

Life Sciences, Cell Biology, Immunology +10

RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition

Lishan Fang, Dane Ford-Roshon, Max Russo et al. · Nature Communications · 2022 · 49 citations · Full text

Medicine, Oncology, Pharmacology +16

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer et al. · Nature Communications · 2024 · 33 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13